Search results for "G quadruplex binding"

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Discovery of new G-quadruplex binding chemotypes

2013

We report here on the discovery and preliminary evaluation of a novel non-macrocyclic low molecular weight quadruplex-stabilizing chemotype. The lead compounds, based on a furan core, show high G-quadruplex stabilisation and selectivity as well as potent in vitro anti-proliferative activity.

Cell SurvivalAntineoplastic Agents010402 general chemistryG-quadruplex01 natural sciencesArticleCatalysis03 medical and health scienceschemistry.chemical_compoundCell Line TumorFuranMaterials ChemistryHumansheterocyclic compoundsFuransCell survival030304 developmental biologyG quadruplex binding0303 health sciencesG-quadruplexChemotypeChemistryCircular DichroismMetals and AlloysGeneral ChemistryCombinatorial chemistryIn vitro3. Good health0104 chemical sciencesSurfaces Coatings and FilmsElectronic Optical and Magnetic MaterialsG-QuadruplexesCeramics and CompositesSelectivityChem. Commun.
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On the G‐Quadruplex Binding of a New Class of Nickel(II), Copper(II), and Zinc(II) Salphen‐Like Complexes

2021

Inorganic ChemistryNickelchemistryPolymer chemistrychemistry.chemical_elementZincCopperG quadruplex bindingddc:
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